Well, in the beginning on the game you don't have a ton of options, but Life Siphon and Conjure Phantasm will get you through a heck of a lot. As the game gets harder you'll have to adapt and use different skills, but those two are probably staples for a while - they will lose effectivenessas health goes up as they deal a pretty flat 2 pip/5 pip degeneration (well, yuou can hit 3 pips with siphon, but not for a long while).
If you use necro for some damage dealing, necro for debuffing melee and a few choice mesmer skills for vs casters you should be fine in PvE for a while.
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